Transporter-mediated Flavonoid-drug Interactions: In Vitro and in Vivo

Transporter-mediated Flavonoid-drug Interactions: In Vitro and in Vivo

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In summary, this dissertation characterized the flavonoid-drug interactions mediated by the uptake and efflux transporters. This research is of significance due to the widespread use of dietary supplements containing flavonoids, and provides new information on the pharmacokinetics and pharmacodynamics of this important class of dietary compounds.Dietary effects on drug pharmacokinetics have been well documented 1, 2. A number of mechanisms are responsible for food-drug interactions, including alterations in physiological conditions (e.g., gastric pH, gastric emptying, intestinalanbsp;...


Title:Transporter-mediated Flavonoid-drug Interactions: In Vitro and in Vivo
Author: Xiaodong Wang
Publisher:ProQuest - 2007
ISBN-13:

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